APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division

Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

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Reis, A., Chang, HY., Levasseur, M. et al. APC^cdh1 activity in mouse oocytes prevents entry into the first meiotic division. Nat Cell Biol 8, 539–540 (2006). https://doi.org/10.1038/ncb1406

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