Author: ["Manojkumar A. Puthenveedu","Collin Bachert","Sapna Puri","Frederick Lanni","Adam D. Linstedt"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.
Cite this article
Puthenveedu, M., Bachert, C., Puri, S. et al. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. Nat Cell Biol 8, 238–248 (2006). https://doi.org/10.1038/ncb1366