Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
Author: ["James I. Elliott","Annmarie Surprenant","Federica M. Marelli-Berg","Joanne C. Cooper","Robin L. Cassady-Cain","Carol Wooding","Kenneth Linton","Denis R. Alexander","Christopher F. Higgins"]
Publication: Nature Cell Biology
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Abstract
Phosphatidylserine (PS) exposure is normally associated with apoptosis and the removal of dying cells. We observed that PS is exposed constitutively at high levels on T lymphocytes that express low levels of the transmembrane tyrosine phosphatase CD45RB. CD45 was shown to be a negative regulator of PS translocation in response to various signals, including activation of the ATP receptor P2X7. Changes in PS distribution were shown to modulate several membrane activities: Ca2+ and Na+ uptake through the P2X7 cation channel itself; P2X7-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein. The data identify a role for PS distribution changes in signal transduction, rapidly modulating the activities of several membrane proteins. This seems to be an all-or-none effect, coordinating the activity of most or all the molecules of a target protein in each cell. The data also suggest a new approach to circumventing multidrug resistance.
Cite this article
Elliott, J., Surprenant, A., Marelli-Berg, F. et al. Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nat Cell Biol 7, 808–816 (2005). https://doi.org/10.1038/ncb1279
