Author: ["Viviane Tabar","Mark Tomishima","Georgia Panagiotakos","Sayaka Wakayama","Jayanthi Menon","Bill Chan","Eiji Mizutani","George Al-Shamy","Hiroshi Ohta","Teruhiko Wakayama","Lorenz Studer"]
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Abstract
Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.Cite this article
Tabar, V., Tomishima, M., Panagiotakos, G. et al. Therapeutic cloning in individual parkinsonian mice. Nat Med 14, 379–381 (2008). https://doi.org/10.1038/nm1732 