Author: ["Pisana Moroni Rawson","Caroline Molette","Melissa Videtta","Laura Altieri","Debora Franceschini","Tiziana Donato","Luigi Finocchi","Antonella Propato","Marino Paroli","Francesca Meloni","Claudio M Mastroianni","Gabriella d'Ettorre","John Sidney","Alessandro Sette","Vincenzo Barnaba"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
We found that the proteome of apoptotic T cells includes prominent fragments of cellular proteins generated by caspases and that a high proportion of distinct T cell epitopes in these fragments is recognized by CD8+ T cells during HIV infection. The frequencies of effector CD8+ T cells that are specific for apoptosis-dependent epitopes correlate with the frequency of circulating apoptotic CD4+ T cells in HIV-1–infected individuals. We propose that these self-reactive effector CD8+ T cells may contribute to the systemic immune activation during chronic HIV infection. The caspase-dependent cleavage of proteins associated with apoptotic cells has a key role in the induction of self-reactive CD8+ T cell responses, as the caspase-cleaved fragments are efficiently targeted to the processing machinery and are cross-presented by dendritic cells. These findings demonstrate a previously undescribed role for caspases in immunopathology.Cite this article
Rawson, P., Molette, C., Videtta, M. et al. Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Nat Med 13, 1431–1439 (2007). https://doi.org/10.1038/nm1679 