Author: ["Chengyang Liu","Hooman Noorchashm","Jennifer A Sutter","Mina Naji","Eline Luning Prak","Jean Boyer","Taryn Green","Michael R Rickels","John E Tomaszewski","Brigitte Koeberlein","Zhonglin Wang","Michelle E Paessler","Ergun Velidedeoglu","Susan Y Rostami","Ming Yu","Clyde F Barker","Ali Naji"]
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Abstract
We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.Cite this article
Liu, C., Noorchashm, H., Sutter, J. et al. B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. Nat Med 13, 1295–1298 (2007). https://doi.org/10.1038/nm1673 