Author: ["Hania Kebir","Katharina Kreymborg","Igal Ifergan","Aurore Dodelet-Devillers","Romain Cayrol","Monique Bernard","Fabrizio Giuliani","Nathalie Arbour","Burkhard Becher","Alexandre Prat"]
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Abstract
TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, TH17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.Cite this article
Kebir, H., Kreymborg, K., Ifergan, I. et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13, 1173–1175 (2007). https://doi.org/10.1038/nm1651 