Author: ["Yuxing Li","Stephen A Migueles","Brent Welcher","Krisha Svehla","Adhuna Phogat","Mark K Louder","Xueling Wu","George M Shaw","Mark Connors","Richard T Wyatt","John R Mascola"]
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Abstract
We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1–infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.Cite this article
Li, Y., Migueles, S., Welcher, B. et al. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat Med 13, 1032–1034 (2007). https://doi.org/10.1038/nm1624 