Author: ["Abhay Sagare","Rashid Deane","Robert D Bell","Bradley Johnson","Katie Hamm","Ronan Pendu","Andrew Marky","Peter J Lenting","Zhenhua Wu","Troy Zarcone","Alison Goate","Kevin Mayo","David Perlmutter","Mireia Coma","Zhihui Zhong","Berislav V Zlokovic"]
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Abstract
Low-density lipoprotein receptor–related protein-1 (LRP) on brain capillaries clears amyloid β-peptide (Aβ) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Aβ in humans. Recombinant LRP cluster IV (LRP-IV) bound Aβ in plasma in mice and Alzheimer's disease–affected humans with compromised sLRP-mediated Aβ binding, and reduced Aβ-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Aβ.Cite this article
Sagare, A., Deane, R., Bell, R. et al. Clearance of amyloid-β by circulating lipoprotein receptors. Nat Med 13, 1029–1031 (2007). https://doi.org/10.1038/nm1635 