Author: ["Seung-Hyo Lee","Sangeeta Goswami","Ariel Grudo","Li-zhen Song","Venkata Bandi","Sheila Goodnight-White","Linda Green","Joan Hacken-Bitar","Joseph Huh","Faisal Bakaeen","Harvey O Coxson","Sebastian Cogswell","Claudine Storness-Bliss","David B Corry","Farrah Kheradmand"]
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Abstract
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.Cite this article
Lee, SH., Goswami, S., Grudo, A. et al. Antielastin autoimmunity in tobacco smoking–induced emphysema. Nat Med 13, 567–569 (2007). https://doi.org/10.1038/nm1583 