Author: ["Brian L Bishop","Mathew J Duncan","Jeongmin Song","Guojie Li","David Zaas","Soman N Abraham"]
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Abstract
The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular E. coli.Cite this article
Bishop, B., Duncan, M., Song, J. et al. Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med 13, 625–630 (2007). https://doi.org/10.1038/nm1572 