Author: ["Christel Rousseaux","Xavier Thuru","Agathe Gelot","Nicolas Barnich","Christel Neut","Laurent Dubuquoy","Caroline Dubuquoy","Emilie Merour","Karen Geboes","Mathias Chamaillard","Arthur Ouwehand","Greg Leyer","Didier Carcano","Jean-Frédéric Colombel","Denis Ardid","Pierre Desreumaux"]
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Abstract
Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.Cite this article
Rousseaux, C., Thuru, X., Gelot, A. et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med 13, 35–37 (2007). https://doi.org/10.1038/nm1521 