Author: ["Tetsuo Sasano","Amy D McDonald","Kan Kikuchi","J Kevin Donahue"]
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Abstract
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.Cite this article
Sasano, T., McDonald, A., Kikuchi, K. et al. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med 12, 1256–1258 (2006). https://doi.org/10.1038/nm1503 