Author: ["Tong Cheng","Anthony L Petraglia","Zhang Li","Meenakshisundaram Thiyagarajan","Zhihui Zhong","Zhenhua Wu","Dong Liu","Sanjay B Maggirwar","Rashid Deane","José A Fernández","Barbra LaRue","John H Griffin","Michael Chopp","Berislav V Zlokovic"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Brain hemorrhage is a serious complication of tissue plasminogen activator (tPA) therapy for ischemic stroke. Here we report that activated protein C (APC), a plasma serine protease with systemic anticoagulant, anti-inflammatory and antiapoptotic activities, and direct vasculoprotective and neuroprotective activities, blocks tPA-mediated brain hemorrhage after transient brain ischemia and embolic stroke in rodents. We show that APC inhibits a pro-hemorrhagic tPA-induced, NF-κB–dependent matrix metalloproteinase-9 pathway in ischemic brain endothelium in vivo and in vitro by acting through protease-activated receptor 1. The present findings suggest that APC may improve thrombolytic therapy for stroke, in part, by reducing tPA-mediated hemorrhage.Cite this article
Cheng, T., Petraglia, A., Li, Z. et al. Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage. Nat Med 12, 1278–1285 (2006). https://doi.org/10.1038/nm1498 