A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines
Author: ["Amin Moghaddam","Wieslawa Olszewska","Belinda Wang","John S Tregoning","Rebecca Helson","Quentin J Sattentau","Peter J M Openshaw"]
Publication: Nature Medicine
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Abstract
Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (TH2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.
Cite this article
Moghaddam, A., Olszewska, W., Wang, B. et al. A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med 12, 905–907 (2006). https://doi.org/10.1038/nm1456
