The autoimmune regulator (Aire) controls iNKT cell development and maturation
Author: ["Qing-Sheng Mi","Zhong-Bin Deng","Sunil K Joshi","Zai-Zhao Wang","Li Zhou","Sarah Eckenrode","Ratanmani Joshi","Dalam Ly","Bing Yi","Terry L Delovitch","Jin-Xiong She"]
Publication: Nature Medicine
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Abstract
The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1. NOTE: We are retracting this report as it contains several errors, including duplications and manipulations of some flow cytometry plots in Figure 1a and in Supplementary Figure 2 online, incorrect juxtaposition of data in Figure 1g (spleen) that in fact derive from different experiments, and inaccurate reporting of the absolute number of iNKT cells and s.d. values, even though the statistical significance remains unchanged. Although original data exist for each figure that largely support the conclusions drawn, we believe that the number of figures affected means that the appropriate response is to retract this paper.
Cite this article
Mi, QS., Deng, ZB., Joshi, S. et al. The autoimmune regulator (Aire) controls iNKT cell development and maturation. Nat Med 12, 624–626 (2006). https://doi.org/10.1038/nm1424
