Author: ["Hikaru Takeda","Stephen Lyle","Alexander J F Lazar","Christos C Zouboulis","Ian Smyth","Fiona M Watt"]
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Abstract
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to β-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of β-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.Cite this article
Takeda, H., Lyle, S., Lazar, A. et al. Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med 12, 395–397 (2006). https://doi.org/10.1038/nm1386 