Author: ["Kenneth Cardona","Gregory S Korbutt","Zvonimir Milas","James Lyon","Jose Cano","Wanhong Jiang","Hameeda Bello-Laborn","Brad Hacquoil","Elizabeth Strobert","Shivaprakash Gangappa","Collin J Weber","Thomas C Pearson","Ray V Rajotte","Christian P Larsen"]
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Abstract
We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.Cite this article
Cardona, K., Korbutt, G., Milas, Z. et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 12, 304–306 (2006). https://doi.org/10.1038/nm1375 