Author: ["Vladimir P Badovinac","Kelly A N Messingham","Ali Jabbari","Jodie S Haring","John T Harty"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4–6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-γ receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-γ on the responding T cells, control the rate of development of memory CD8+ T cells.Cite this article
Badovinac, V., Messingham, K., Jabbari, A. et al. Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med 11, 748–756 (2005). https://doi.org/10.1038/nm1257 