Author: ["Kenji Kuwaki","Yau-Lin Tseng","Frank J M F Dor","Akira Shimizu","Stuart L Houser","Todd M Sanderson","Courtney J Lancos","Derek D Prabharasuth","Jane Cheng","Kathleen Moran","Yosuke Hisashi","Nicolas Mueller","Kazuhiko Yamada","Julia L Greenstein","Robert J Hawley","Clive Patience","Michel Awwad","Jay A Fishman","Simon C Robson","Henk-Jan Schuurman","David H Sachs","David K C Cooper"]
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Abstract
Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody–based regimen. The elimination of the galactose-α1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2–6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.Cite this article
Kuwaki, K., Tseng, YL., Dor, F. et al. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 11, 29–31 (2005). https://doi.org/10.1038/nm1171 