Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
Author: ["Alberto Lleó","Oksana Berezovska","Lauren Herl","Susan Raju","Amy Deng","Brian J Bacskai","Matthew P Frosch","Michael Irizarry","Bradley T Hyman"]
Publication: Nature Medicine
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Abstract
Recent reports suggest that some commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) unexpectedly shift the cleavage products of amyloid precursor protein (APP) to shorter, less fibrillogenic forms, although the underlying mechanism remains unknown. We now demonstrate, using a fluorescence resonance energy transfer method, that Aβ42-lowering NSAIDs specifically affect the proximity between APP and presenilin 1 and alter presenilin 1 conformation both in vitro and in vivo, suggesting a novel allosteric mechanism of action.
Cite this article
Lleó, A., Berezovska, O., Herl, L. et al. Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation. Nat Med 10, 1065–1066 (2004). https://doi.org/10.1038/nm1112
