Author: ["Héctor G Pálmer","María Jesús Larriba","José Miguel García","Paloma Ordóñez-Morán","Cristina Peña","Sandra Peiró","Isabel Puig","Rufo Rodríguez","Ricardo de la Fuente","Antonio Bernad","Marina Pollán","Félix Bonilla","Carlos Gamallo","Antonio García de Herreros","Alberto Muñoz"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)2D3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.Cite this article
Pálmer, H., Larriba, M., García, J. et al. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 10, 917–919 (2004). https://doi.org/10.1038/nm1095 