Author: ["Min-Seon Kim","Joong-Yeol Park","Cherl Namkoong","Pil-Geum Jang","Je-Won Ryu","Hai-Sun Song","Ji-Young Yun","Il-Seong Namgoong","Joohun Ha","In-Sun Park","In-Kyu Lee","Benoit Viollet","Jang Hyun Youn","Hong-Kyu Lee","Ki-Up Lee"]
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Abstract
AMP-activated protein kinase (AMPK) functions as a fuel sensor in the cell and is activated when cellular energy is depleted. Here we report that α-lipoic acid (α-LA), a cofactor of mitochondrial enzymes, decreases hypothalamic AMPK activity and causes profound weight loss in rodents by reducing food intake and enhancing energy expenditure. Activation of hypothalamic AMPK reverses the effects of α-LA on food intake and energy expenditure. Intracerebroventricular (i.c.v.) administration of glucose decreases hypothalamic AMPK activity, whereas inhibition of intracellular glucose utilization through the administration of 2-deoxyglucose increases hypothalamic AMPK activity and food intake. The 2-deoxyglucose-induced hyperphagia is reversed by inhibiting hypothalamic AMPK. Our findings indicate that hypothalamic AMPK is important in the central regulation of food intake and energy expenditure and that α-LA exerts anti-obesity effects by suppressing hypothalamic AMPK activity. NOTE: In the version of this article initially published online, the name of an author was misspelled. The name of the twelfth author should be “Benoit Viollet”. This error has been corrected for the HTML and print versions of the articleCite this article
Kim, MS., Park, JY., Namkoong, C. et al. Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10, 727–733 (2004). https://doi.org/10.1038/nm1061 