Author: ["O Andréoletti","S Simon","C Lacroux","N Morel","G Tabouret","A Chabert","S Lugan","F Corbière","P Ferré","G. Foucras","H. Laude","F. Eychenne","J Grassi","F Schelcher"]
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Abstract
Because variant Creutzfeldt–Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrPSc in a myocyte subset. In naturally infected sheep, PrPSc is detectable in muscle several months before clinical disease onset. The relative amounts of PrPSc suggest a 5,000-fold lower infectivity for muscle as compared to brain.Cite this article
Andréoletti, O., Simon, S., Lacroux, C. et al. PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med 10, 591–593 (2004). https://doi.org/10.1038/nm1055 