The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Author: ["Davide Ruggero","Lorenzo Montanaro","Li Ma","Wei Xu","Paola Londei","Carlos Cordon-Cardo","Pier Paolo Pandolfi"]
Publication: Nature Medicine
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Abstract
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
Cite this article
Ruggero, D., Montanaro, L., Ma, L. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10, 484–486 (2004). https://doi.org/10.1038/nm1042
