Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis
Author: ["Fred S Harman","Christopher J Nicol","Holly E Marin","Jerrold M Ward","Frank J Gonzalez","Jeffrey M Peters"]
Publication: Nature Medicine
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Abstract
Peroxisome proliferator–activated receptor-δ (PPAR-δ; also known as PPAR-β) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-δ in colon carcinogenesis using PPAR-δ-deficient (Ppard−/− ) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-δ. In contrast to previous reports suggesting that activation of PPAR-δ potentiates colon polyp formation, here we show that PPAR-δ attenuates colon carcinogenesis.
Cite this article
Harman, F., Nicol, C., Marin, H. et al. Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis. Nat Med 10, 481–483 (2004). https://doi.org/10.1038/nm1026
