A new role for Nogo as a regulator of vascular remodeling
Author: ["Lisette Acevedo","Jun Yu","Hediye Erdjument-Bromage","Robert Qing Miao","Ji-Eun Kim","David Fulton","Paul Tempst","Stephen M Strittmatter","William C Sessa"]
Publication: Nature Medicine
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Abstract
Although Nogo-A has been identified in the central nervous system as an inhibitor of axonal regeneration, the peripheral roles of Nogo isoforms remain virtually unknown. Here, using a proteomic analysis to identify proteins enriched in caveolae and/or lipid rafts (CEM/LR), we show that Nogo-B is highly expressed in cultured endothelial and smooth muscle cells, as well as in intact blood vessels. The N terminus of Nogo-B promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle (VSM) cells, processes necessary for vascular remodeling. Vascular injury in Nogo-A/B-deficient mice promotes exaggerated neointimal proliferation, and adenoviral-mediated gene transfer of Nogo-B rescues the abnormal vascular expansion in those knockout mice. Our discovery that Nogo-B is a regulator of vascular homeostasis and remodeling broadens the functional scope of this family of proteins.
Cite this article
Acevedo, L., Yu, J., Erdjument-Bromage, H. et al. A new role for Nogo as a regulator of vascular remodeling. Nat Med 10, 382–388 (2004). https://doi.org/10.1038/nm1020
