Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Author: ["Vicente E Torres","Xiaofang Wang","Qi Qian","Stefan Somlo","Peter C Harris","Vincent H Gattone II"]
Publication: Nature Medicine
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Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2−/tm1Som), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function.
Cite this article
Torres, V., Wang, X., Qian, Q. et al. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 10, 363–364 (2004). https://doi.org/10.1038/nm1004
