HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
Author: ["Christophe Nicot","Miroslav Dundr","Julie M Johnson","Jake R Fullen","Norma Alonzo","Risaku Fukumoto","Gerald L Princler","David Derse","Tom Misteli","Genoveffa Franchini"]
Publication: Nature Medicine
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30II is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression1,2, their inhibition by p30II reduces virion production. p30II inhibits virus expression by reducing Tax and Rex protein expression.
Cite this article
Nicot, C., Dundr, M., Johnson, J. et al. HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med 10, 197–201 (2004). https://doi.org/10.1038/nm984
