Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells
Author: ["Hajime Hisaeda","Yoichi Maekawa","Daiji Iwakawa","Hiroko Okada","Kunisuke Himeno","Kenji Kishihara","Shin-ichi Tsukumo","Koji Yasutomo"]
Publication: Nature Medicine
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Abstract
Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4+CD25+ regulatory T cells (Treg) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of Treg cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.
Cite this article
Hisaeda, H., Maekawa, Y., Iwakawa, D. et al. Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells. Nat Med 10, 29–30 (2004). https://doi.org/10.1038/nm975
