Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
Author: ["H Rosie Xing","Carlos Cordon-Cardo","Xinzhu Deng","William Tong","Luis Campodonico","Zvi Fuks","Richard Kolesnick"]
Publication: Nature Medicine
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Abstract
Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.
Cite this article
Xing, H., Cordon-Cardo, C., Deng, X. et al. Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med 9, 1267–1268 (2003). https://doi.org/10.1038/nm927
