Author: ["Bob Olsson","Per-Ola Andersson","Margareta Jernås","Stefan Jacobsson","Björn Carlsson","Lena M S Carlsson","Hans Wadenvik"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.Cite this article
Olsson, B., Andersson, PO., Jernås, M. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9, 1123–1124 (2003). https://doi.org/10.1038/nm921 