Author: ["Markus Feuerer","Philipp Beckhove","Natalio Garbi","Yolanda Mahnke","Andreas Limmer","Mirja Hommel","Günter J Hämmerling","Bruno Kyewski","Alf Hamann","Viktor Umansky","Volker Schirrmacher"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Although bone marrow is known as a primary lymphoid organ, its potential to serve as a secondary immune organ has hardly been explored. Here we demonstrate that naive, antigen-specific T cells home to bone marrow, where they can be primed. Antigen presentation to T cells in bone marrow is mediated via resident CD11c+ dendritic cells. They are highly efficient in taking up exogenous blood-borne antigen and processing it via major histocompatibility complex class I and class II pathways. T-cell activation correlates with dendritic cell–T cell clustering in bone marrow stroma. Primary CD4+ and CD8+ T-cell responses generated in bone marrow occur in the absence of secondary lymphoid organs. The responses are not tolerogenic and result in generation of cytotoxic T cells, protective anti-tumor immunity and immunological memory. These findings highlight the uniqueness of bone marrow as an organ important for hemato- and lymphopoiesis and for systemic T cell–mediated immunity.Cite this article
Feuerer, M., Beckhove, P., Garbi, N. et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med 9, 1151–1157 (2003). https://doi.org/10.1038/nm914 