Author: ["Janet D Siliciano","Joleen Kajdas","Diana Finzi","Thomas C Quinn","Karen Chadwick","Joseph B Margolick","Colin Kovacs","Stephen J Gange","Robert F Siliciano"]
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Abstract
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t1/2 = 44 months) that eradication is unlikely.Cite this article
Siliciano, J., Kajdas, J., Finzi, D. et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9, 727–728 (2003). https://doi.org/10.1038/nm880 