Author: ["Patrizia Barozzi","Mario Luppi","Fabio Facchetti","Cristina Mecucci","Milena Alù","Ronit Sarid","Valeria Rasini","Luisa Ravazzini","Elisa Rossi","Silvana Festa","Barbara Crescenzi","Dana G. Wolf","Thomas F. Schulz","Giuseppe Torelli"]
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Abstract
Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8–infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8–specific T cells for the control of post-transplant KS.Cite this article
Barozzi, P., Luppi, M., Facchetti, F. et al. Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med 9, 554–561 (2003). https://doi.org/10.1038/nm862 