Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

Abstract

Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-β2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.

Cite this article

Sohn, JH., Bora, P., Suk, HJ. et al. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 9, 206–212 (2003). https://doi.org/10.1038/nm814

View full text

>> Full Text:   Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells