Author: ["Anders H. Berg","Terry P. Combs","Xueliang Du","Michael Brownlee","Philipp E. Scherer"]
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Abstract
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2–3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.Cite this article
Berg, A., Combs, T., Du, X. et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7, 947–953 (2001). https://doi.org/10.1038/90992 