Author: ["Joseph Wolfers","Anne Lozier","Graça Raposo","Armelle Regnault","Clotilde Théry","Carole Masurier","Caroline Flament","Stéphanie Pouzieux","Florence Faure","Thomas Tursz","Eric Angevin","Sebastian Amigorena","Laurence Zitvogel"]
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Abstract
The initiation of T-cell–mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell–dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.Cite this article
Wolfers, J., Lozier, A., Raposo, G. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7, 297–303 (2001). https://doi.org/10.1038/85438 