Author: ["Laura A. Napolitano","Robert M. Grant","Steven G. Deeks","Diane Schmidt","Stephen C. De Rosa","Leonore A. Herzenberg","Brian G. Herndier","Jan Andersson","Joseph M. McCune"]
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Abstract
We hypothesized that HIV-1–mediated T-cell loss might induce the production of factors that are capable of stimulating lymphocyte development and expansion. Here we perform cross-sectional (n = 168) and longitudinal (n = 11) analyses showing that increased circulating levels of interleukin (IL)-7 are strongly associated with CD4+ T lymphopenia in HIV-1 disease. Using immunohistochemistry with quantitative image analysis, we demonstrate that IL-7 is produced by dendritic-like cells within peripheral lymphoid tissues and that IL-7 production by these cells is greatly increased in lymphocyte-depleted tissues. We propose that IL-7 production increases as part of a homeostatic response to T-cell depletion.Cite this article
Napolitano, L., Grant, R., Deeks, S. et al. Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7, 73–79 (2001). https://doi.org/10.1038/83381 