Author: ["Yu-quan Wei","Qing-ru Wang","Xia Zhao","Li Yang","Ling Tian","You Lu","Bin Kang","Chong-jiu Lu","Mei-juan Huang","Yan-yan Lou","Fei Xiao","Qiu-ming He","Jing-mei Shu","Xing-jiang Xie","Yun-qiu Mao","Shong Lei","Feng Luo","Li-qun Zhou","Chong-en Liu","Hao Zhou","Yu Jiang","Feng Peng","Liang-ping Yuan","Qiu Li","Yang Wu","Ji-yan Liu"]
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Abstract
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction. Cite this article
Wei, Yq., Wang, Qr., Zhao, X. et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine . Nat Med 6, 1160–1166 (2000). https://doi.org/10.1038/80506 