Author: ["Wolfram Jochum","Jean-Pierre David","Candace Elliott","Anton Wutz","Hanns Plenk Jr.","Koichi Matsuo","Erwin F. Wagner"]
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Abstract
Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.Cite this article
Jochum, W., David, JP., Elliott, C. et al. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6, 980–984 (2000). https://doi.org/10.1038/79676 