Author: ["Mette D. Hazenberg","Sigrid A. Otto","James W.T. Cohen Stuart","Martie C.M. Verschuren","Jan C.C. Borleffs","Charles A.B. Boucher","Roel A. Coutinho","Joep M.A. Lange","Tobias F. Rinke de Wit","Aster Tsegaye","Jacques J.M. van Dongen","Dörte Hamann","Rob J. de Boer","Frank Miedema"]
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Abstract
Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.Cite this article
Hazenberg, M., Otto, S., Stuart, J. et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med 6, 1036–1042 (2000). https://doi.org/10.1038/79549 