Characterization of a newly discovered T-cell receptor β-chain heterodimer expressed on a CD8+ bone

Abstract

The facilitating cell is a rare CD8+ bone marrow subpopulation that can enhance allogeneic hematopoietic stem cell engraftment across complete major histocompatibility complex barriers without inducing acute graft-versus-host disease. Here we describe a CD3ɛ-associated complex on the facilitating cell surface that consists of the T-cell receptor β-chain disulfide-linked to a previously unknown 33-kilodalton glycoprotein. Provisionally called FCp33, this glycoprotein does not represent any of the known protein chains or surrogates associated with CD3–T-cell receptor β. Expression of this CD3–T-cell receptor β–FCp33 complex directly correlates with the facilitating cell's functional ability to enhance allogeneic stem cell engraftment in vivo.

Cite this article

Schuchert, M., Wright, R. & Colson, Y. Characterization of a newly discovered T-cell receptor β-chain heterodimer expressed on a CD8⁺ bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nat Med 6, 904–909 (2000). https://doi.org/10.1038/78667

View full text

>> Full Text:   Characterization of a newly discovered T-cell receptor β-chain heterodimer expressed on a CD8+ bone