Author: ["Fernando P. Polack","Sok H. Lee","Sallie Permar","Elizabeth Manyara","Hossein G. Nousari","Yaikah Jeng","Farah Mustafa","Alexandra Valsamakis","Robert J. Adams","Harriet L. Robinson","Diane E. Griffin"]
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Abstract
Measles remains a principal cause of worldwide mortality, in part because young infants cannot be immunized effectively. Development of new vaccines has been hindered by previous experience with a formalin-inactivated vaccine that predisposed to a severe form of disease (atypical measles). Here we have developed and tested potential DNA vaccines for immunogenicity, efficacy and safety in a rhesus macaque model of measles. DNA protected from challenge with wild-type measles virus. Protection correlated with levels of neutralizing antibody and not with cytotoxic T lymphocyte activity. There was no evidence in any group, including those receiving hemagglutinin-encoding DNA alone, of ‘priming’ for atypical measles.Cite this article
Polack, F., Lee, S., Permar, S. et al. Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Nat Med 6, 776–781 (2000). https://doi.org/10.1038/77506 