➦   Latrunculin alters the actin-monomer subunit interface to prevent polymerization

➦   Smooth-muscle contraction without smooth-muscle myosin

➦   The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

➦   A regulatory link between ER-associated protein degradation and the unfolded-protein response.

➦   Intercellular communication mediated by the extracellular calcium-sensing receptor

➦   ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

➦   ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

➦   LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis e

➦   Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B

➦   Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

➦   A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

➦   Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel

➦   A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryon

➦   Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms.

➦   Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

➦   Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites.

➦   Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apo

➦   Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

➦   CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic check

➦   Negative regulation of the Apaf-1 apoptosome by Hsp70

➦   Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression

➦   Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precociou

➦   The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

➦   Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

➦   p95-APP1 links membrane transport to Rac-mediated reorganization of actin

➦   A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

➦   BAX-dependent transport of cytochrome c reconstituted in pure liposomes

➦   Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

➦   The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylatio

➦   Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafi

➦   An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

➦   Anaphase spindle position is monitored by the BUB2 checkpoint

➦   Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins

➦   The MDM2 RING-finger domain is required to promote p53 nuclear export

➦   Inhibition of RhoA by p120 catenin

➦   Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the ap

➦   The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly

➦   Functional localization of single active ion channels on the surface of a living cell

➦   Hsp27 negatively regulates cell death by interacting with cytochrome c

➦   Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42

➦   Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

➦   Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite funct

➦   The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation

➦   Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover

➦   Annexation of the interchromosomal space during viral infection

➦   Polo-like kinase-1 is a target of the DNA damage checkpoint

➦   Mechanical control of cyclic AMP signalling and gene transcription through integrins

➦   Intrinsic lattice formation by the ryanodine receptor calcium-release channel

➦   Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synth

➦   OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity