Author: ["Hafid Ait-Oufella","Benoît L Salomon","Stéphane Potteaux","Anna-Karin L Robertson","Pierre Gourdy","Joffrey Zoll","Régine Merval","Bruno Esposito","José L Cohen","Sylvain Fisson","Richard A Flavell","Göran K Hansson","David Klatzmann","Alain Tedgui","Ziad Mallat"]
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Abstract
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke1,2. Here, we show that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens3,4, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.Cite this article
Ait-Oufella, H., Salomon, B., Potteaux, S. et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12, 178–180 (2006). https://doi.org/10.1038/nm1343 