Author: ["Antonella Folgori","Stefania Capone","Lionello Ruggeri","Annalisa Meola","Elisabetta Sporeno","Bruno Bruni Ercole","Monica Pezzanera","Rosalba Tafi","Mirko Arcuri","Elena Fattori","Armin Lahm","Alessandra Luzzago","Alessandra Vitelli","Stefano Colloca","Riccardo Cortese","Alfredo Nicosia"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Three percent of the world's population is chronically infected with the hepatitis C virus (HCV) and at risk of developing liver cancer. Effective cellular immune responses are deemed essential for spontaneous resolution of acute hepatitis C and long-term protection. Here we describe a new T-cell HCV genetic vaccine capable of protecting chimpanzees from acute hepatitis induced by challenge with heterologous virus. Suppression of acute viremia in vaccinated chimpanzees occurred as a result of massive expansion of peripheral and intrahepatic HCV-specific CD8+ T lymphocytes that cross-reacted with vaccine and virus epitopes. These findings show that it is possible to elicit effective immunity against heterologous HCV strains by stimulating only the cellular arm of the immune system, and suggest a path for new immunotherapy against highly variable human pathogens like HCV, HIV or malaria, which can evade humoral responses.Cite this article
Folgori, A., Capone, S., Ruggeri, L. et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 12, 190–197 (2006). https://doi.org/10.1038/nm1353 