Author: ["Julien Taieb","Nathalie Chaput","Cédric Ménard","Lionel Apetoh","Evelyn Ullrich","Mathieu Bonmort","Marie Péquignot","Noelia Casares","Magali Terme","Caroline Flament","Paule Opolon","Yann Lecluse","Didier Métivier","Elena Tomasello","Eric Vivier","François Ghiringhelli","François Martin","David Klatzmann","Thierry Poynard","Thomas Tursz","Graça Raposo","Hideo Yagita","Bernard Ryffel","Guido Kroemer","Laurence Zitvogel"]
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Abstract
The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C− dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2−/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.Cite this article
Taieb, J., Chaput, N., Ménard, C. et al. A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med 12, 214–219 (2006). https://doi.org/10.1038/nm1356 