Author: ["Gang Chen","Hua Qian","Thomas Starzl","Hongtao Sun","Bertha Garcia","Ximo Wang","Yishai Wise","Yuanqing Liu","Ying Xiang","Laura Copeman","Weihua Liu","Anthony Jevnikar","William Wall","David K C Cooper","Noriko Murase","Yifan Dai","Wanyu Wang","Yuliang Xiong","David J White","Robert Zhong"]
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Abstract
We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.Cite this article
Chen, G., Qian, H., Starzl, T. et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 11, 1295–1298 (2005). https://doi.org/10.1038/nm1330 