Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

Abstract

The Arctic mutation within the amyloid-β (Aβ) peptide causes Alzheimer disease. In vitro, Arctic-mutant Aβ forms (proto)fibrils more effectively than wild-type Aβ. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type Aβ, even though Arctic mice had lower Aβ1-42/1-40 ratios. Thus, the Arctic mutation is highly amyloidogenic in vivo.

Cite this article

Cheng, I., Palop, J., Esposito, L. et al. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 10, 1190–1192 (2004). https://doi.org/10.1038/nm1123

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